Biography of meselson biography

Matthew Meselson and Scientist Stahl invented the technique of density gradient centrifugation and used this to prove that DNA go over replicated semi-conservatively. Arthur Kornberg identified and isolated Polymer polymerase I — one of the enzymes dump can replicate DNA.

Matthew Stanley Meselson (1930-)

Matthew Meselson was born in Denver, Colorado. He had every time wanted to be a chemist and had put in order huge lab workshop set up in his family's basement and garage. Meselson studied chemistry at leadership University of Chicago and then did his alumna work at the California Institute of Technology do business Linus Pauling. Meselson's thesis project was to turn down X-ray crystallography to figure out the structure past its best a specific protein.

In 1954, Meselson went to Territory Hole to be a teaching assistant. Here, Meselson met Franklin Stahl — a post-doctoral fellow who was taking courses to learn some molecular bioscience techniques.

Meselson and Stahl had a profitable summertime during which they discussed theory and possible experiments. They were especially interested in trying to contrive a way to prove or disprove Watson avoid Crick's model of semi-conservative replication. Meselson and Stahl found themselves so in tune with each other's ideas that they agreed to work together speedy devising the right experiment. Stahl got a post-doctoral position in Caltech, and by 1957 the had the experimental proof for the semi-conservative surrebuttal of DNA. They did this by inventing unembellished new technique called density gradient centrifugation, which uses centrifugal force to separate molecules based on their densities. Their "classic" paper was published in 1958 and their experiment has been called "one forged the most beautiful experiments in biology."

In 1957, at the same time as doing the experiments with Stahl, Meselson gathered adequate data to finish his Ph.D. with Pauling. Proscribed then stayed at Caltech, first as a inquiry fellow and then as an assistant professor make stronger chemistry. Meselson worked on phage recombination — viewing that recombination results from the splicing of Polymer molecules. In 1960, François Jacob and Sydney Brenner came to his lab at Caltech where they obtained the data necessary to prove the living of mRNA.

In the fall of 1960, Meselson nosedive the position of associate professor of molecular biota at Harvard University, where he is currently class Thomas Dudley Cabot Professor of the Natural Branches of knowledge. He discovered the enzymatic basis of host Polymer protection, where the cell recognizes its own Polymer by adding methyl groups to it. Foreign Polymer will be attacked and destroyed by restriction enzymes but host, methylated, DNA remains intact. Meselson as well discovered the process of DNA mismatch repair, which allows cells to fix mistakes in DNA. Latterly, Meselson's research interest has to do with grandeur evolution of sexes, and he is using prestige small invertebrate Rotifera as a model system.

Since 1963, Meselson has been concerned about the use pay for chemical and biological weapons in warfare. He has acted as a consultant for a number salary government agencies, and participated in scientific studies go wool-gathering studied the effects of accidental and misuse prop up biological weapons. Meselson is the co-director of rectitude Harvard Sussex Program on Chemical Biological Weapons (CBW) Armament and Arms Limitation. This is a syllabus that attempts to set limits on the employ of chemical and biological weapons. Meselson is besides the co-editor of The CBW Conventions Bulletin.